BioWorld: Fluorination Propels SciFluor into 'Billion-Dollar' Markets


Fluorination Propels SciFluor Into ‘Billion-Dollar’ Markets 
By Marie Powers Staff Writer 

Nearly one in four marketed drugs contains the chemical element fluorine, including household names for vastly different indications such as Lipitor (atorvastatin, Pfizer Inc.), Cipro (ciprofloxacin, Bayer AG) and Prozac (fluoxetine, Eli Lilly and Co.) The reason? The carbon-fluorine bond, the strongest in organic chemistry, is widely used to block sites of metabolism and improve drug half-life. Using fluorine to modify the chemical structure of a drug has been demonstrated to improve potency, selectivity, tissue penetration, half-life and metabolic stability.

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